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Fertility in male rats was fentanyl unaffected at 400 micrograms/kg/day intravenously .
In a two-year carcinogenicity study in rats, fentanyl was not associated with an increased fentanyl incidence of tumours at subcutaneous doses up to 33 micrograms/kg/day in males or 100 micrograms/kg/day in females, which were the respective maximum tolerated doses .
Fentanyl showed no evidence of genotoxic potential in assays for gene mutations (Ames reverse mutation test, mouse lymphoma thymidine kinase assay), chromosomal fentanyl damage (Chinese hamster ovary cells, mouse micronucleus test) and other genotoxic effects SUBLIMAZE(190315)PPI (unscheduled DNA synthesis in rat hepatocytes, mammalian cell transformation assay) .
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