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Hartrick et al14 also reported non-inferior analgesic efficacy and superior gastrointestinal tolerability of tapentadol immediate release (50 or 75mg) compared with oxycodone immediate release (10 mg) in a 10-day phase III, randomized, doubleblind, active- and placebo-controlled study in 666 patients with pain related to degenerative joint disease palexia awaiting primary joint replacement .
In the phase III, randomized, double-blind, active controlled, parallel group, multi-centre, 90-day safety study in 849 patients with lower back pain or osteoarthritis of the hip or knee, tapentadol immediate release substantially better gastrointestinal tolerability while achieving palexia similar analgesic efficacy compared with oxycodone HCl immediate release22; the mean total daily dose was 284mg in the tapentadol immediate release group and 42mg in the oxycodone immediate release group .
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